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offered its significant function in immunity, It isn't shocking that excess MIF expression is associated with exaggerated inflammation and immunopathology. On top of that, MIF demonstrates very well-documented proliferative Qualities. MIF is secreted by many different types of cells and interacts with quite a few receptors, which allows to elucidat
that is definitely, stimulation of CD74 with exogenous MIF could possibly bring on an extreme inflammatory point out, as MIF is effective at stimulating CXCR2 and CXCR4 receptors Along with CD74. CXCR2 and CXCR4 receptors when activated get more info endorse inflow of neutrophils and lymphocytes, respectively (sixty three, sixty four). Fig. 4: Dia